Best answer: Is ondansetron safe during first trimester?

Is ondansetron safe in first trimester of pregnancy?

A new study from Brigham and Women’s Hospital finds that pregnant women taking the common anti-nausea medication ondansetron during the first trimester have no increased risk of cardiac malformations and only a slight increased risk of oral clefts.

Can you take Zofran at 6 weeks pregnant?

A new study published in the New England Journal of Medicine concluded that the popular drug Zofran (used to treat nausea, vomiting and in some cases, hyperemesis gravidarum, in early pregnancy) poses no risk to the developing fetus.

Can ondansetron cause miscarriage?

Ondansetron used after around week 10 of pregnancy would not be able to cause these problems as the baby is fully developed by this stage. There are no concerns that ondansetron use in pregnancy affects the chance of miscarriage, stillbirth, preterm delivery or low infant birth weight.

Can you take nausea medicine in first trimester?

In fact, the FDA has approved a prescription medication for use during pregnancy that is a combination of Vitamin B6 and Unisom. It is called Diclegis. This is the only FDA approved medication for treating nausea and vomiting during pregnancy.

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Can I take Zofran 8 weeks pregnant?

Taking Zofran while pregnant is low risk, and it has been prescribed for years for pregnancy nausea. That said, Zofran for pregnancy nausea is an off-label use, and there may be better options.

Can ondansetron cause birth defects?

The results of these studies have concluded Zofran causes birth defects, particularly congenital heart defects, cleft palate defects, and kidney defects. The birth defects linked to use of Zofran during pregnancy include: 130% risk of overall birth defects.

Will Zofran hurt my unborn baby?

If you are pregnant and have taken ondansetron or Zofran® during pregnancy, I want to reassure you that it likely has not affected your baby. Even if the increased risk for cleft palate or heart defects turns out to be true, the risk to your baby is still very, very small.

Does ondansetron work for morning sickness?

Ondansetron (Zofran®) is a medicine used to treat nausea and vomiting that may be caused by surgery, chemotherapy, or radiation therapy. Healthcare professionals also prescribe ondansetron during pregnancy to reduce symptoms of nausea and vomiting, also known as “morning sickness.”

What can I take for nausea while pregnant?

If your morning sickness symptoms persist, your health care provider may recommend vitamin B-6 supplements (pyridoxine), ginger and over- the-counter options such as doxylamine (Unisom) for management. If you still have symptoms, your health care provider may recommend prescription anti-nausea medications.

Does ondansetron cross the placenta?

Based on the findings of our analysis, ondansetron dosing does not need to be altered in pregnancy, and it readily crosses the placenta. However, a dosage adjustment is required in neonates because of its longer half-life, which is likely to be due to reduced clearance.

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Is ondansetron safe after 12 weeks?

Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy. Recent epidemiological studies suggest exposure to ondansetron during the first trimester of pregnancy is associated with a small increased risk of the baby having a cleft lip and/or cleft palate.

What pregnancy category is ondansetron?

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.