Is it okay to take acyclovir while pregnant?
Conclusion: Use of acyclovir in the first trimester does not increase birth defects, and it should be the antiviral drug of choice in early pregnancy.
What can acyclovir cause while being pregnant?
Acyclovir, an antiviral nucleoside analogue, is a widely used agent highly specific for herpes simplex and varicella-zoster viruses. Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.
Does acyclovir cause birth defects?
This study also included dermatological acyclovir exposure in early pregnancy (n = 474) and found no association with birth defects. A study using prescription data and questionnaire information on pregnancy outcomes found no birth defects in 22 pregnancies exposed to acyclovir or famciclovir.
Is acyclovir safe in third trimester?
Answer Studies have shown that the use of acyclovir or valacyclovir is not associated with an increase in birth defects. Limited data exist for famciclovir and therefore it would not be considered a first-line choice for treatment of herpes during pregnancy.
Does acyclovir cause miscarriage?
Miscarriage can occur in any pregnancy. Studies have not found an increased chance for miscarriage following acyclovir use.
How much acyclovir is safe during pregnancy?
Both the American College of Obstetricians and Gynecologists and the Centers for Disease Control and Prevention recommend the following dosages during pregnancy: acyclovir: 400-mg doses three times per day. valacyclovir: 500-mg doses twice per day.
Treatment with antiviral medications is recommended for pregnant women or women who are up to 2 weeks postpartum (including following pregnancy loss) with suspected or confirmed influenza and can be taken during any trimester of pregnancy.
Does acyclovir cross the placenta?
Acyclovir is known to cross the placenta to the fetus. Frenkel et al4 reported the specific pharmacokinetics of acyclovir in pregnant patients with recurrent HSV receiv ing either 200 or 400 mg of acyclovir orally every 8 hours from 38 weeks’ gestation until delivery.
What category is acyclovir for pregnancy?
All formulations of acyclovir are assigned FDA pregnancy category C status ****, which indicates that safety in human pregnancies has not been determined; therefore, the drug should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.
What happens if you get shingles when pregnant?
If you have shingles during pregnancy it won’t harm your baby. Your immunity to chickenpox will help to protect your unborn baby. Shingles appears as a painful rash of tiny blisters, which can occur anywhere on the body, but most commonly on the chest or stomach.