How long can you live with osteogenesis imperfecta?
The median survival time in the OI cohort was 72.4 years for males (compared to 81.5 years in the reference population) and 77.4 for females (compared to 84.5 in the reference population).
How long do babies with osteogenesis imperfecta live?
Life expectancy for males with OI was 9.5 years shorter than that for the general population (72.4 years vs 81.9 years), and for females, was 7.1 years shorter than that for the general population (77.4 years vs 84.5 years).
Does OI get worse with age?
In type 3 OI, your child’s body produces enough collagen but it’s poor quality. Your child’s bones can even begin to break before birth. Bone deformities are common and may get worse as your child gets older.
How does OI affect the lungs?
OI Affects the Lungs
The primary respiratory problem affecting people with OI is loss of lung capacity. Other problems include ineffective cough, poor secretion clearance, airway diseases such as asthma, sleep apnea, and low oxygen. These problems affect people of all ages and all types of OI.
Does osteogenesis imperfecta affect the brain?
Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by disruption of normal collagen formation resulting in varying degrees of skeletal vulnerability, ligamentous laxity, and scleral discoloration. Children with OI may suffer from complex neurosurgical problems affecting the brain and spine.
How many babies are born with osteogenesis imperfecta?
OI is a disease characterized by brittle bones and frequent fractures with minimal trauma leading to skeletal deformities . Its incidence is estimated at 1 per 20,000 births . Though rare, it is the most common inherited disorder of connective tissue.
Can babies be born with fractures?
Osteogenesis imperfecta (OI) is an inherited (genetic) bone disorder that is present at birth. It’s also known as brittle bone disease. A child born with OI may have soft bones that break (fracture) easily, bones that are not formed normally, and other problems. Signs and symptoms may range from mild to severe.
Why does OI cause blue sclera?
Blue sclera is the most commonly known ocular sign for osteogenesis imperfecta and it is caused by thin scleral collagen allowing the underlying darker choroid vasculature to be seen. Patients with OI have shown a reduction in thickness of the corneal and scleral collagen fibers which can result in low ocular rigidity.
Can people with osteogenesis walk?
The type of OI was strongly associated with current walking ability, as was the presence of dentinogenesis imperfecta. Patients with type III and IV had a lower chance of ultimately walking compared with those with type I.
What is OI type 3 severe?
Type III osteogenesis imperfecta — people with type III OI usually will be shorter than their peers, and may have severe bone deformities, breathing problems (which can be life-threatening), brittle teeth, a curved spine, ribcage deformities, and other problems.